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Caffeine is actually a stimulant and may reduce the calming consequences of diazepam. It is best not to get drinks like espresso, tea, cola and Electrical power beverages since they contain caffeine.Metabolism: Diazepam is mostly broken down by the microsomal enzymes CYP2C19 and CYP3A4 enzymes to many active metabolites, mostly desmethyldiazepam